NCT07419711

Grape Polyphenols for Prevention of Chemotherapy-Induced Cardiotoxicity

Cardioprotective Effects of Grape Polyphenols to Reduce Chemotherapy-Induced Cardiotoxicity in Breast Cancer Patients: A Randomized Pilot Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Nazarbayev University · Academic / Other
• Sex: Female
• Age: 30 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This pilot randomized clinical study aims to evaluate the cardioprotective effects of a grape polyphenol concentrate in patients receiving anthracycline- and/or trastuzumab-based chemotherapy. Adult patients at high or very high risk of chemotherapy-induced cardiotoxicity will be randomized to receive either a grape polyphenol concentrate or placebo for three months, starting with chemotherapy. Cardiac function and cardiotoxicity will be assessed using echocardiographic parameters and circulating biomarkers at baseline, 3 months, and 6 months.

Conditions

• Chemotherapy-induced Cardiotoxicity
• Breast Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Grape Polyphenol Concentrate	Grape polyphenol concentrate, 20 mg/mL; participants take 15 mL orally once daily for 3 months starting with chemotherapy.
OTHER	Placebo (Dark Grape Juice)	Placebo (dark grape juice); participants take 15 mL orally once daily for 3 months starting with chemotherapy.

Timeline

• Start date: 2026-02-09
• Primary completion: 2026-05-09
• Completion: 2027-11-01
• First posted: 2026-02-19
• Last updated: 2026-02-19