NCT07419594

Estradiol and Intrusive Memories

The Effect of Estradiol on the Acquisition and Consolidation of Trauma-Associated Memories

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 273 (estimated)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.

Conditions

• PTSD
• Intrusive Memories
• Intrusion Symptom
• Trauma
• Intrusion

Interventions

Type	Name	Description
DRUG	Estradiol Valerate	3mg of Estradiol Valerate pills, administred orally
DRUG	Placebo	Plabo pill

Timeline

• Start date: 2024-08-19
• Primary completion: 2027-12-31
• Completion: 2028-02-29
• First posted: 2026-02-19
• Last updated: 2026-02-19

Locations

1 site across 1 country: Germany