NCT07418788

Polymeric Nano Calcium Fluoride Varnish, Diode Laser, and Their Combination for Dentin Hypersensitivity

Efficacy of Polymeric Nano Calcium Fluoride Varnish, Diode Laser Individually and in Combination in the Treatment of Dentin Hypersensitivity.

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Faculty of Dental Medicine for Girls · Other Government
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to assess the effect of polymeric nano calcium fluoride Varnish (Oli-NANO seal), 976 nm diode laser solely and combination of both therapies in the treatment of dentin hypersensitivity

Conditions

• Dentin Hypersensitivity, Non-carious Cervical Lesions
• Gingival Recession Localized Moderate

Interventions

Type	Name	Description
OTHER	Olinano seal	The OliNANO seal is "varnish-like" shield which is based on nanotechnology that allows an optimum adhesion to enamel and dentin, it could be used as an effective desensitizing agent by forming a protective layer that occludes the dentinal tubules which can be effective for a year as mentioned by the manufacturer. Polymeric nano calcium fluoride varnish consists of four main components, silicone polymer, NANO-fluorapatite, nano-calcium fluoride and amine fluoride (Olaflur)
DEVICE	Diode Laser	increase in the metabolic activity of odontoblasts. Thus, obliteration of the dentinal tubules and formation of tertiary dentin.
OTHER	Olinano seal and Diode Laser	Combined methods have been also evaluated in some previous studies. It showed more effect in reducing Dentin hypersensitivity than using every treatment solely

Timeline

• Start date: 2025-05-15
• Primary completion: 2025-07-10
• Completion: 2026-07-16
• First posted: 2026-02-18
• Last updated: 2026-02-18

Locations

1 site across 1 country: Egypt