NCT07418580

Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery

The Effects of Perioperative Low-dose Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Sisli Hamidiye Etfal Training and Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Effective postoperative analgesia after lumbar spine surgery (e.g., laminectomy, vertebroplasty, lumbar stabilization) is associated with faster recovery and shorter hospital stay. Multimodal analgesia aims to reduce opioid consumption and related adverse effects by combining agents with complementary mechanisms of action at peripheral and central levels. Magnesium is one of the agents used in this approach. Its analgesic effects are attributed to inhibition of neuropathic pain, potentiation of opioid analgesia, and attenuation of opioid tolerance. Mechanistically, magnesium acts as a non-competitive NMDA receptor antagonist and modulates intracellular calcium influx, thereby reducing central glutamate release and limiting hyperalgesia. However, the clinical efficacy of perioperative magnesium remains controversial. Outcomes may vary depending on timing (intraoperative vs. postoperative), dosing strategies (bolus vs. infusion), and total administered dose. The optimal dosage, administration method, safety profile, and dose-response relationship of magnesium for analgesic purposes are not yet clearly established. This study aims to evaluate the effectiveness of perioperative low-dose magnesium sulfate (MgSO₄) in this context.

Conditions

• Postoperative Pain
• Back Pain Lower Back Chronic

Interventions

Type	Name	Description
DRUG	Magnesium sulfate	Initial serum magnesium levels of the patients were measured at the beginning of the surgery; and subsequently an infusion of MgSO4 (10 mg/kg/h) in 100 mL of normal saline (NS) was initiated in groups C, respectively.
DRUG	normal saline	Initial serum magnesium levels of the patients were measured at the beginning of the surgery; and subsequently an infusion of 100 mL of NS (10 mg/kg/h) was initiated in groups m, respectively.

Timeline

• Start date: 2021-04-01
• Primary completion: 2021-11-01
• Completion: 2021-11-30
• First posted: 2026-02-18
• Last updated: 2026-02-18

Locations

1 site across 1 country: Turkey (Türkiye)