NCT07416929

Manual Therapy and Inspiratory Muscle Training in Neuromuscular Disease

Effects of Combined Manual Therapy and Inspiratory Muscle Training on Respiratory Function, Dyspnea and Trunk Control in Neuromuscular Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Istinye University · Academic / Other
• Sex: All
• Age: 7 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The benefits of inspiratory muscle training (IMT) have been reported in neuromuscular diseases. However, its effects are limited. Further research is needed in new and complementary modalities demonstrating IMT efficacy in neuromuscular diseases. This study aimed to investigate the effect of combined IMT and manual therapy in neuromuscular diseases. Twenty-eight children with a diagnosis of muscle disease were included in the study. Only conventional physiotherapy program was applied to the control group. In the study group, in addition to the conventional physiotherapy program, manual therapy techniques were applied 3 days a week and IMT 2 times a day, 5 days a week for 6 weeks. Lung function test, respiratory muscle strength, fatigue and dyspnea assessment, corbin posture analysis, sit-reach test, functional reach test (FRT), timed up and go test (TUG), motor function measure (MFM) and trunk impairment scale (TIS) were used in the evaluations.

Conditions

• Neuromuscular Disease
• Inspiratory Muscle Training
• Manual Therapy

Interventions

Type	Name	Description
OTHER	inspiratory muscle training	IMT was performed using the Threshold IMT (Respironics, USA) respiratory training device with threshold loading technique at 30% of maximum inspiratory pressure for 15 minutes twice a day (total of 30 minutes daily), 5 days a week for 6 weeks. The new maximum inspiratory pressure was measured every week, and the respiratory exercise device resistance was adjusted according to the new value and the workload was increased
OTHER	Manual therapy	Suboccipital release, rib raising, diaphragm, anterior thoracic and sternal myofascial release, anterior cervical myofascial release, costal ligament release, lymph pump, scalene, pectoral, latissimus dorsi and serratus anterior energy techniques were used as the manual therapy approach. Myofascial release techniques were applied for 1-3 minutes each. Mobilisation was performed for 30 seconds and 5 repetitions in each joint. The manual therapy protocol session lasted 20-25 minutes. The manual therapy protocol was applied 3 days a week for 6 weeks, for a total of 18 sessions
OTHER	Conventional physiotherapy programme	Conventional physiotherapy includes therapeutic, strengthening and stretching exercises, electrotherapy approaches to pain

Timeline

• Start date: 2021-08-15
• Primary completion: 2022-01-15
• Completion: 2022-08-15
• First posted: 2026-02-18
• Last updated: 2026-04-13

Locations

1 site across 1 country: Turkey (Türkiye)