NCT07416136

The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus.

Investigation of the Effects of Chlorhexidine Gluconate + Benzydamine Hydrochloride and Chlorhexidine Gluconate + Flurbiprofen on Pain, Edema, and Trismus Following Mandibular Impacted Third Molar Extraction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Marmara University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study aims to compare the effects of two commonly used topical mouth sprays on pain, swelling, and limitation of mouth opening after surgical removal of impacted lower wisdom teeth. A total of 40 adult patients who require the removal of both lower impacted wisdom teeth will participate in this study. Each patient will undergo two separate surgical procedures, with a healing period between them. After each surgery, one of the two topical agents will be applied to the surgical area. The order of the treatments will be randomly assigned. The study is designed so that neither the patients nor the clinician evaluating the outcomes will know which topical agent is used at each session. Pain levels, facial swelling, and mouth opening will be measured at specific time points after surgery. The results will help determine whether one topical treatment is more effective than the other in reducing postoperative discomfort and improving recovery. The information obtained from this study may contribute to improving postoperative care following wisdom tooth surgery.

Conditions

• Impacted Mandibular Third Molar

Interventions

Type	Name	Description
DRUG	Kloroben topical spray	Kloroben topical spray containing chlorhexidine gluconate and benzydamine hydrochloride is applied to the surgical site immediately after impacted mandibular third molar extraction and used postoperatively according to the study protocol to reduce pain, swelling, and trismus.
DRUG	Klorhex Plus topical spray	Klorhex Plus topical spray containing chlorhexidine gluconate and flurbiprofen is applied to the surgical site immediately after impacted mandibular third molar extraction and used postoperatively according to the study protocol to reduce pain, swelling, and trismus.

Timeline

• Start date: 2025-04-20
• Primary completion: 2025-08-15
• Completion: 2025-10-19
• First posted: 2026-02-17
• Last updated: 2026-03-25

Locations

1 site across 1 country: Turkey (Türkiye)