NCT07415434

Laser-assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation

Laser-Assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation: A Randomized Placebo-Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: University of Gaziantep · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This randomized placebo-controlled clinical trial aimed to evaluate the effect of laser-assisted therapy on soft tissue healing at the pontic site prior to fixed partial denture rehabilitation. Clinical healing outcomes, postoperative pain levels, and gingival crevicular fluid transforming growth factor beta-2 (TGF-β2) levels were assessed to determine the biological and clinical effects of laser therapy compared with placebo.

Detailed description

Delayed or compromised soft tissue healing at the pontic site may prolong prosthetic treatment and negatively affect tissue stability and patient comfort. Photobiomodulation has been reported to enhance wound healing and modulate inflammatory and regenerative processes. This randomized placebo-controlled clinical trial evaluated the clinical and biological effects of laser-assisted therapy on pontic site healing prior to fixed partial denture rehabilitation. Clinical healing index scores, wound dimensions, postoperative pain levels, and gingival crevicular fluid TGF-β2 levels were assessed to investigate both clinical and biological aspects of healing.

Conditions

• Soft Tissue Healing

Interventions

Type	Name	Description
DEVICE	GRR laser	Low-level laser therapy applied once daily for five consecutive days following tooth extraction to enhance soft tissue healing at the pontic site.
DEVICE	Nd:YAG laser	Nd:YAG laser therapy applied once daily for five consecutive days following tooth extraction to promote soft tissue healing.
OTHER	Sham laser	Placebo laser application performed under identical conditions without energy delivery.

Timeline

• Start date: 2025-03-15
• Primary completion: 2025-05-15
• Completion: 2025-06-15
• First posted: 2026-02-17
• Last updated: 2026-02-17

Locations

1 site across 1 country: Turkey (Türkiye)