NCT07413055

Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial

Comparative Efficacy of 4 mg vs. 8 mg Submucosal Dexamethasone in Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 138 (estimated)
• Sponsor: Oman Ministry of Health · Other Government
• Sex: All
• Age: 21 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the effectiveness of 4mg and 8mg dexamethasone administered submucosally in reducing postoperative pain after dental implant surgery. Participants will be randomly assigned to receive either 4mg dexamethasone, 8mg dexamethasone, or a placebo (normal saline) at the surgical site. Later, postoperative pain will be assessed using a Visual Analog Scale at 6 hours after the surgery and daily for the next 6 days. Also the number of pain-relief tablets consumed after the surgery will be recorded. Preoperative anxiety will be assessed using Generalized Anxiety Disorder-7 (GAD-7) questionnaire to assess its association with postoperative pain scores. The results of this study will help determine the optimal dose of dexamethasone that is effective for postoperative pain control following dental implant surgery.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Dexamethasone 4 Mg/mL Injectable Solution	Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule
DRUG	Dexamethasone 8Mg Solution for Injection	Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule
DRUG	Saline (NaCl 0,9 %) (placebo)	Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule

Timeline

• Start date: 2026-03-25
• Primary completion: 2026-11-15
• Completion: 2026-12-01
• First posted: 2026-02-17
• Last updated: 2026-03-30

Locations

1 site across 1 country: Oman