NCT07411638

Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: National Skin Centre · Network
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study aims to uncover the specific immunopathology, microbiome and pathophysiology of acne vulgaris in people living in a tropical climate such as Singapore. This is a largely unexplored population in terms of acne pathogenesis, and will lead to population-specific interventions for the management of acne vulgaris.

Detailed description

The main objective of this translational study in healthy participants and in mild, moderate and severe acne participants is to deepen the current understanding of acne aetiology. A multi-omics approach will be leveraged to analyse the interactions between the local skin microbiota and host factors found in different stages of acne vulgaris and generate hypotheses on how these may contribute to different disease manifestations. General objectives: I. Deepen the current understanding of acne aetiology II. Identify key biological markers of disease severity and specific immune pathways III. Describe bacterial components associated with disease severity and inflammatory immune response IV. Determine antigens of the natural immune response against C. acnes Data collected from participants includes: * Demographic Data \[age, sex, ethnicity, body mass index (BMI)\] * Skin type (using the Fitzpatrick skin classification scale) Samples collected from participants: * Pore Strip Application (comedo extraction) * Facial swabbing * Facial tape stripping * Blood Samples * Facial biopsies (optional)

Conditions

• Acne

Timeline

• Start date: 2026-02-15
• Primary completion: 2028-02-14
• Completion: 2029-02-14
• First posted: 2026-02-17
• Last updated: 2026-02-17