NCT07410065

Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight

Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight (HOPE)

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Center for Health Sciences, Serbia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. By enrolling outpatients across multiple centers and applying rigorous blinding and randomization procedures, HOPE aims to generate high-quality clinical evidence on the potential role of hydrogen-rich water as a non-pharmacological, adjunctive strategy for weight management and metabolic health.

Conditions

• Overweight

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Hydrogen-rich water	Hydrogen-rich water (1.0 L per day)
DIETARY_SUPPLEMENT	Control	Hydrogen-free water (1.0 L per day)

Timeline

• Start date: 2026-04-15
• Primary completion: 2027-01-15
• Completion: 2027-02-15
• First posted: 2026-02-13
• Last updated: 2026-02-13

Locations

1 site across 1 country: Serbia