NCT07409883

Association Between Slow Wave Activity and Sleep Inertia

Association Between Slow Wave Activity and Sleep Inertia in Nighttime Simulated Naps: An Observational Study With Nap Intervention

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 28 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Observational study: The goal of this observational study is to learn about the association between slow wave activity before awakening and post-awakening psychomotor vigilance task in time-fixed, 2-hour, simulated night naps in healthy individuals. The main question aims to answer is: Is the quantity of slow wave activity immediately before awakening associated with post-awakening psychomotor vigilance task metrics when awakened after 2-hour nap at night?

Detailed description

Sleepiness and fatigue are common complaints among shift workers, especially night shift workers. Napping interventions before a work shift have been reported to increase alertness and reduce accidents. However, naps may also result in impaired cognition for a brief period immediately after awakening, known as "sleep inertia", which can be particularly problematic in on-call settings and may require a worker to delay the return to work for up to about 30 minutes after waking. Although, nap duration less than 30 minutes, theoretically, may produce less intense sleep inertia. However, evidence regarding nap duration aiming to mitigate sleepiness and fatigue is mixing. We thus aimed to investigate the association between slow wave activity (SWA) assessed by EEG power spectral analysis during the last 10 minutes before awakening and 10-minute psychomotor vigilance test (PVT) immediately after awakening and 30 minutes after awakening in healthy participants on simulated night shift scenarios.

Conditions

• Sleep, Slow-wave Sleep, Sleep Enhancement, Sleep Optimization
• Sleep Inertia
• Night Shift Work

Interventions

Type	Name	Description
BEHAVIORAL	Nap intervention	Nap intervention is the protocol that allows the participant to sleep from 11:00 PM to 2:00 AM, then woken up.

Timeline

• Start date: 2026-02-04
• Primary completion: 2026-04-15
• Completion: 2026-08-30
• First posted: 2026-02-13
• Last updated: 2026-02-13

Locations

1 site across 1 country: Thailand