NCT07407361

Comparison of Allograft, Xenograft and Combined Grafting in Maxillary Sinus Augmentation

Radiographic, Histological and Immunohistochemical Evaluation of Allograft, Xenograft, and Combined Grafting in Maxillary Sinus Floor Augmentation: A Prospective Randomized Clinical Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Tokat Gaziosmanpasa University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This prospective randomized clinical study evaluates and compares three different grafting approaches (allograft, xenograft, and combined grafting) used in lateral maxillary sinus augmentation prior to dental implant placement. Patients with posterior maxillary bone deficiency (residual bone height ≤4 mm) undergoing sinus lift surgery were randomly assigned to one of three grafting groups. Cone-beam computed tomography (CBCT) was used to assess bone height before surgery, immediately after grafting, and at 6 months. During implant placement at 6 months, bone biopsy samples were collected from the grafted sites for histological and immunohistochemical evaluation. The study aims to assess vertical bone gain, graft height stability, and biological bone healing using osteocalcin, osteopontin, and RUNX2 markers. The results are intended to provide clinically relevant information regarding the volumetric and biological behavior of different graft materials used in maxillary sinus augmentation.

Conditions

• Posterior Maxillary Atrophy
• Maxillary Sinus Augmentation

Interventions

Type	Name	Description
PROCEDURE	Lateral Maxillary Sinus Augmentation with Allograft	Lateral sinus floor elevation was performed using allograft material prior to dental implant placement.
PROCEDURE	Lateral Maxillary Sinus Augmentation with Xenograft	Lateral sinus floor elevation was performed using xenograft material prior to dental implant placement.
PROCEDURE	Lateral Maxillary Sinus Augmentation with Combined Graft	Lateral sinus floor elevation was performed using a combination of allograft and xenograft materials prior to dental implant placement.
PROCEDURE	Dental Implant Placement Without Sinus Augmentation	Dental implant placement was performed without sinus augmentation. Bone biopsy samples were obtained from the implant site during implant placement for histological and immunohistochemical evaluation.

Timeline

• Start date: 2022-06-30
• Primary completion: 2024-04-24
• Completion: 2024-04-24
• First posted: 2026-02-12
• Last updated: 2026-02-12

Locations

1 site across 1 country: Turkey (Türkiye)