NCT07403955

The Effect of Dapagliflozin on Myocardial Strain in Patients With Acute Heart Failure

A Randomized Controlled Clinical Study on the Effect of Dapagliflozin on Myocardial Strain in Patients With Acute Heart Failure

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 188 (estimated)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to assess the impact of dapagliflozin on myocardial strain in patients with acute heart failure using speckle tracking echocardiography (STE). The main questions it aims to answer are: * Does dapagliflozin improve left ventricular remodeling as well as cardiac systolic and diastolic function? * Can STE more accurately assess the impact of dapagliflozin on myocardial strain in patients with acute heart failure? Researchers will compare patients receiving oral dapagliflozin to those not receiving it to see if dapagliflozin works to improve left ventricular remodeling as well as cardiac systolic and diastolic function. Participants will: * Take dapagliflozin or not every day for 1 month * Take dapagliflozin for the next 2 months * Visit the clinic at Month 1 and Month 3 for checkups and tests

Conditions

• Congestive Heart Failure Acute

Interventions

Type	Name	Description
DRUG	Dapagliflozin 10mg Tab	Compared with the control group, dapagliflozin is started within the first month after the onset of acute heart failure.

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-12-01
• Completion: 2028-12-01
• First posted: 2026-02-11
• Last updated: 2026-03-24