NCT07402109

CBCT Guided Markerless SBRT for Renal Cell Cancer

Organ Sparing Marker-less CBCT-guided Stereotactic Adaptive Radiotherapy for Primary Non-metastasized Renal Tumors

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to improve the treatment of kidney tumors using radiotherapy, by investigating whether kidney cancer can be more effectively irradiated with the help of new imaging techniques

Detailed description

In total 40 patients will be treated for RCC using SBRT. For 15 patients, additional breath-hold CBCT scans will be made during SBRT to investigate the intra- and inter-fraction uncertainty in breath-hold positions as well as assessing the feasibility of using surface guidance as a surrogate for target position. Subsequently, 25 patients will be treated using the new motion management technique developed using the extra imaging data obtained from the first cohort of patients. It is hypothesized that either breath-hold or gating in combination with surface guidance will result in a reproducible (stable) position of the target and therefore minimal margins.

Conditions

• Renal Cell Carcinoma (RCC)

Interventions

Type	Name	Description
RADIATION	Additional radiation due to imaging	Additional imaging will be done using CT, therefore the patient will receive additional radiation dose

Timeline

• Start date: 2026-04-01
• Primary completion: 2030-01-01
• Completion: 2030-01-01
• First posted: 2026-02-11
• Last updated: 2026-04-08

Locations

1 site across 1 country: Netherlands