NCT07400991

Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure

Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure: a Randomized Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 420 (estimated)
• Sponsor: Gødstrup Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF). The study will also assess the safety of the intervention and its effects on thirst and quality of life. Patients hospitalized with ADHF will be asked to follow either a thirst-driven fluid-intake strategy or a fluid-restriction strategy during their hospital stay and for one month after discharge.

Conditions

• Acute Heart Failure (AHF)

Interventions

Type	Name	Description
BEHAVIORAL	Fluid restriction strategy	Fluid restriction of 1.5 L/day
BEHAVIORAL	Thirst-driven, liberal fluid intake	Liberal fluid intake driven by thirst without restrictions

Timeline

• Start date: 2026-05-01
• Primary completion: 2029-05-01
• Completion: 2029-08-01
• First posted: 2026-02-10
• Last updated: 2026-02-12

Locations

1 site across 1 country: Denmark