NCT07400432

Acute Effects of Moderate-Intensity Continuous Exercise Versus HIIT on Cognitive Performance and Psychophysiological Responses in Physically Active Adults

Acute Effects of Moderate-Intensity Continuous Exercise Versus High-Intensity Interval Training on Cognitive Performance and Psychophysiological Responses in Physically Active Adults: A Randomized Crossover Study

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (estimated)
• Sponsor: Qassim University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study aims to compare the immediate effects of two common types of exercise-moderate-intensity continuous exercise and high-intensity interval training (HIIT)-on attention, alertness, and physiological responses in physically active young adults. Attention and mental alertness are essential for learning, academic performance, and daily functioning. Previous research suggests that a single session of exercise can temporarily improve cognitive performance, but it is not clear whether moderate exercise or high-intensity interval exercise is more effective in producing these immediate benefits. In this study, participants will complete two supervised treadmill exercise sessions on separate days: one session of moderate-intensity continuous exercise and one session of high-intensity interval training. The order of the two exercise sessions will be randomized, and there will be a rest period of 48 to 72 hours between sessions. Before and immediately after each exercise session, participants will complete computerized cognitive tests that measure sustained attention and reaction time. Heart rate, oxygen saturation, perceived exertion, mood, and alertness will also be measured to evaluate physiological and psychological responses to exercise. By comparing the effects of these two exercise approaches within the same individuals, this study aims to identify which type of exercise leads to better immediate cognitive performance and favorable physiological responses. The findings may help guide exercise recommendations for improving attention, alertness, and overall mental performance in young adults.

Detailed description

This study is a randomized within-subject crossover clinical trial designed to compare the acute effects of moderate-intensity continuous exercise (MICE) and high-intensity interval training (HIIT) on cognitive performance and psychophysiological responses in physically active young adults. Each participant will complete two supervised treadmill exercise sessions-one MICE session and one HIIT session-on separate days, with a 48-72-hour washout period. The order of the two exercise conditions will be randomized using a computer-generated sequence. This crossover design allows each participant to serve as their own control, reducing inter-individual variability and increasing statistical power. Cognitive performance will be assessed immediately before and after each exercise session using validated computerized tests of sustained attention and vigilance, including the Sustained Attention to Response Task (SART) and the Psychomotor Vigilance Task (PVT). Primary cognitive outcomes will include reaction time, accuracy, response inhibition, and attentional lapses. Psychophysiological responses will be monitored throughout the exercise sessions and immediately post-exercise. These include heart rate, oxygen saturation, rating of perceived exertion, mood, and alertness. Exercise intensity will be prescribed based on percentages of age-predicted maximum heart rate and continuously monitored to ensure protocol adherence and participant safety. Data will be analyzed using within-subject statistical comparisons to evaluate differences between exercise conditions. The findings are expected to provide evidence on how acute exercise intensity influences immediate cognitive and physiological responses, informing exercise recommendations for optimizing attention and alertness in young adults.

Conditions

• Sustained Attention
• Cognitive Performance
• Cognitive Performance During Physical Activity

Interventions

Type	Name	Description
OTHER	Moderate-Intensity Continuous Exercise (MICE)	Participants perform continuous treadmill exercise for 20 minutes at 60-70% of age-predicted maximum heart rate. Each session includes a standardized warm-up period of approximately 3 minutes and a cool-down period of 2-3 minutes. Heart rate, oxygen saturation, and rating of perceived exertion are monitored throughout the session to ensure adherence to the target intensity and participant safety.
OTHER	High-Intensity Interval Training (HIIT)	Participants perform treadmill-based high-intensity interval training consisting of repeated short bouts of exercise at 85-95% of age-predicted maximum heart rate, interspersed with brief recovery periods. Total session duration is approximately 20 minutes, including standardized warm-up and cool-down periods. Heart rate, oxygen saturation, and rating of perceived exertion are continuously monitored to ensure safety and protocol compliance.

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-03-01
• Completion: 2026-04-05
• First posted: 2026-02-10
• Last updated: 2026-02-10

Locations

1 site across 1 country: Saudi Arabia