NCT07399223

Comparison of the Metabolomic Effects of Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Harran University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Analytical techniques used in metabolomic studies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The study will involve comparing the metabolomic profiles of patients receiving sevoflurane and desflurane during surgery to identify any differences in metabolic pathways affected by the two anaesthetic techniques. Metabolomic profiles are generated using spectroscopic and spectrometric techniques such as high-field NMR and MS, as well as separation techniques.

Detailed description

Our study will include 100 patients undergoing laparoscopic cholecystectomy surgery, divided into two groups. Patients aged 18-65 years with an ASA I-II classification, who will undergo laparoscopic cholecystectomy surgery, have no active infection, and have a body mass index (BMI) \<35, and who agree to participate in the study, will be intubated after standard anaesthetic induction (propofol, rocuronium, fentanyl) and intubated. The first sample will be taken from the finger immediately after the inhalation anaesthetic (sevoflurane, desflurane) reaches 1 minimal alveolar concentration (MAC) level. The second sample will be taken after the surgical procedure is completed and the inhalation anaesthesia is discontinued. The samples will be taken from the patients' fingertips and absorbed onto Guthrie paper. Statistical analysis will be performed on the data obtained.

Conditions

• Sevoflurane Desflurane
• Metabolomic Effect

Interventions

Type	Name	Description
PROCEDURE	Sevoflurane	This group will be operated on under sevoflurane.
PROCEDURE	Desflurane	This group will be operated on under desflurane.

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-05-15
• Completion: 2026-05-30
• First posted: 2026-02-10
• Last updated: 2026-02-23