NCT07397858

Cognition and Behavior With Sham Accelerated TMS

Studies of Cognition and Behavior Using Sham Accelerated Transcranial Magnetic Stimulation

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 15 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given. The main questions this study aims to answer are: 1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule? 2. Do these expectations influence mood, reward processing, or craving? 3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule? Participants will: * Complete baseline clinical assessments and an MRI session * Undergo five days of accelerated sham TMS (no active brain stimulation is delivered) * Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks

Conditions

• Healthy Participants

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation Sham	All study participants will receive sham TMS (no active stimulation will be provided).

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-08-01
• Completion: 2028-01-01
• First posted: 2026-02-09
• Last updated: 2026-02-09