NCT07395973

The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.

Conditions

• Overweight and Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	ketogenic nutritional Supplement	Daily ketogenic nutritional supplement for 4 weeks
DIETARY_SUPPLEMENT	non-ketogenic, isocaloric control	Daily control for 4 weeks

Timeline

• Start date: 2025-11-25
• Primary completion: 2027-10-31
• Completion: 2027-10-31
• First posted: 2026-02-09
• Last updated: 2026-02-09

Locations

1 site across 1 country: Netherlands