NCT07395895

Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women

Effect of Metformin Iontophoresis Combined With Physical Therapy Rehabilitation on Knee Osteoarthritis in Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 68 (estimated)
• Sponsor: Badr University · Academic / Other
• Sex: Female
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program. Participants will be randomly allocated into either a study group receiving metformin iontophoresis or a control group receiving placebo iontophoresis. Both participants and outcome assessors will be blinded to group allocation.

Detailed description

The study population will consist of postmenopausal women diagnosed with knee osteoarthritis. Postmenopause is defined as the absence of menstruation for at least 12 consecutive months. Participants will be randomly assigned to either the study or control group using a computer-generated randomization sequence. Allocation concealment will be ensured using sealed opaque envelopes. Both participants and outcome assessors will be blinded to the treatment allocation. The physical therapist applying iontophoresis will not be involved in outcome assessment.

Conditions

• Osteoarthritis in Postmenopausal Women

Interventions

Type	Name	Description
DRUG	Metformin gel Iontophoresis	Metformin gel 2% Iontophoresis Combined with Physical Therapy Rehabilitation
DEVICE	Iontophoresis	Iontophoresis with neutral gel Combined with Physical Therapy Rehabilitation

Timeline

• Start date: 2026-03-01
• Primary completion: 2026-04-15
• Completion: 2026-05-01
• First posted: 2026-02-09
• Last updated: 2026-02-09

Locations

1 site across 1 country: Egypt