NCT07395882

A New Model to Induce Itch and Inflammation

Investigating the Neurophysiology of Itch

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This project aims to create a reliable, long-lasting itch model by synergistically combining thermal pre-conditioning with the application of histamine or cowhage.

Detailed description

Two areas (4x4 cm, one on each forearm), will be selected. Initially, superficial blood perfusion will be measured in each area, followed by pruritogens application. During the 10 minutes of the application of the pruritogens, itch will be continuously monitored using a VAS scale. After the pruritogens application, assessment of the superficial blood perfusion (SBP), mechanical sensitivity, and thermal sensitivity will be conducted. The session will be identical to the first session, but pre-heat conditioning will be applied prior to pruritogens application.

Conditions

• Itching

Interventions

Type	Name	Description
OTHER	Cowhage (Mucuna Pruriens)	The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm/face
OTHER	Histamine	To deliver histamine, standard allergy skin prick test (SPT) lancets are applied
OTHER	Heat	45 °C x 5 min

Timeline

• Start date: 2026-02-15
• Primary completion: 2028-12-31
• Completion: 2029-12-31
• First posted: 2026-02-09
• Last updated: 2026-02-11

Locations

1 site across 1 country: Denmark