NCT07395869

Off-set Analgesia Induced by Cold Temperature

Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.

Detailed description

After filling some questionnaires, two areas (4x4 cm, 4 cm apart) will be selected on each forearm of the subjects. The areas will be randomly treated with one of the following trials: hot experimental trial, hot control trial, cold experimental trial, and cold control trial.

Conditions

• Pain

Interventions

Type	Name	Description
OTHER	Heat off-set analgesia	The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device
OTHER	Cold off-set analgesia	The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device.

Timeline

• Start date: 2026-02-15
• Primary completion: 2026-12-31
• Completion: 2028-12-31
• First posted: 2026-02-09
• Last updated: 2026-02-11

Locations

1 site across 1 country: Denmark