NCT07395609

High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With Subjective Cognitive Decline

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 65 Years – 89 Years
• Healthy volunteers: Accepted

Summary

The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in older adults with Subjective Cognitive Decline (SCD), relative to an SCD control group receiving white noise sensory stimulation. Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).

Conditions

• Subjective Cognitive Decline (SCD)
• Healthy Subjects

Interventions

Type	Name	Description
BEHAVIORAL	Flicker Stimulation	Investigators will combine ultrasound (≥22 kHz) and near-infrared two-photon stimulation (890-940 nm) to deliver rhythmic input in a subliminal, comfortable manner, without the side effects associated with visible flicker.
BEHAVIORAL	Sham White Noise Stimulation	The control group will receive white noise sensory stimulation rather than a constant flicker frequency.

Timeline

• Start date: 2026-02-15
• Primary completion: 2028-10-31
• Completion: 2028-10-31
• First posted: 2026-02-09
• Last updated: 2026-02-09

Locations

1 site across 1 country: United States