NCT07394530

Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS

A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Hanoi General Hospital (Vietnam) · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.

Conditions

• Polycystic Ovary Syndrome (PCOS)
• Female Infertility

Interventions

Type	Name	Description
DRUG	Progestin-Primed Ovarian Stimulation (PPOS)	Ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol, including gonadotropins combined with oral progestin for pituitary suppression during in vitro fertilization treatment.
DRUG	GnRH Antagonist Protocol	Ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol for pituitary suppression during in vitro fertilization treatment.

Timeline

• Start date: 2026-01-20
• Primary completion: 2027-06-30
• Completion: 2028-06-30
• First posted: 2026-02-06
• Last updated: 2026-02-11

Locations

1 site across 1 country: Vietnam