NCT07393503

Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries

• Status: Enrolling By Invitation
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: State University of New York at Buffalo · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain: 1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions 2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin) The investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.

Conditions

• Musculoskeletal Pain

Interventions

Type	Name	Description
DRUG	Methylprednisolone 4Mg Tab	Participants follow standard 6- day taper dosing schedule.
DRUG	Acetaminophen 500Mg Tab	Participants follow a 6- day taper dosing schedule.
DRUG	Ibuprofen 200Mg Oral Tablet	Participants follow a 6- day taper dosing schedule.

Timeline

• Start date: 2025-09-17
• Primary completion: 2026-08-01
• Completion: 2027-01-01
• First posted: 2026-02-06
• Last updated: 2026-02-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study