NCT07393165

Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism

The Effect of Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 4 Years – 15 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effect of the treatment with levothyroxine on cardiac function in children with subclinical hypothyroidism.

Detailed description

Subclinical hypothyroidism (SH) is a branch of hypothyroidism which is characterized by increased thyroid stimulating hormone (TSH) and normal thyroxine (T4). Inadequate serum thyroid hormone levels impair cardiac function and may result in multiple cardiovascular risk factors, such as endothelial dysfunction, increased intima-media thickness, increased vascular resistance, and pericardial effusion.

Conditions

• Levothyroxine
• Cardiac Function
• Children
• Subclinical Hypothyroidism

Interventions

Type	Name	Description
DRUG	L-thyroxine	Children with subclinical hypothyroidism who will receive L-thyroxine treatment in a dose of 2μg/kg/d (the smallest dose can be given) and the dose will be titrated every 4 weeks until a normal thyroid-stimulating hormone (TSH) level is maintained.

Timeline

• Start date: 2025-05-24
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2026-02-06
• Last updated: 2026-02-06

Locations

1 site across 1 country: Egypt