NCT07391696

Coffee Intake Biomarker Validation and Association With Respiratory Diseases

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 21 Years – 64 Years
• Healthy volunteers: Accepted

Summary

This proposed project aims to identify and validate biomarkers of coffee exposure in the Singapore population, and assess the association between coffee consumption (via biomarker measurements) and risk of respiratory diseases in a prospective multi-ethnic cohort in Singapore. Specific Aim 1: To identify and quantify urinary/serum metabolite changes that are associated with coffee consumption in a dose-response intervention study.

Conditions

• Coffee

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Coffee A	Week 1: coffee A ≤10 g coffee powder for low dose Week 2: non-coffee consumption (post-consumption kinetics) Week 3: coffee A ≤20 g coffee powder for medium dose Week 4: non-coffee consumption (post-consumption kinetics) Week 5: coffee A ≤40 g coffee powder for high dose Week 6: non-coffee consumption (post-consumption kinetics)
DIETARY_SUPPLEMENT	Coffee B	Week 7: coffee B ≤40 g coffee powder for high dose Week 8: non-coffee consumption (post-consumption kinetics)
DIETARY_SUPPLEMENT	Tea	Week 9: washout Week 10: tea (control) Week 11: non-coffee consumption (post-consumption kinetics)

Timeline

• Start date: 2020-10-01
• Primary completion: 2022-12-31
• Completion: 2026-12-31
• First posted: 2026-02-06
• Last updated: 2026-02-06

Locations

1 site across 1 country: Singapore