NCT07391293

Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 208 (estimated)
• Sponsor: IRCCS Policlinico S. Donato · Academic / Other
• Sex: All
• Age: 14 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of this observational study is to define the behavioural and cardiovascular risk factor profiles of patients with genetic aortopathies. The main questions it aims to answer are: * How do the interconnections between lifestyle, stress, psychological condition, perception of illness, and state of health influence each other in this population? * Beyond traditional risk factors, additional emerging factors should be considered, including pregnancy-related complications, sedentary lifestyle, early menopause and depression. The interplay between eating disorders, lifestyle factors and autoimmune or inflammatory bowel diseases remains poorly understood.

Detailed description

Thoracic aortic aneurysms (TAA) present peculiar symptoms as well as high mortality due to complications related to dilatation and dissection of the ascending aorta and great arteries. The presence or absence of extra-aortic features determines whether TAADs are syndromic, associated with diseases affecting other systems and organs, or non-syndromic, with manifestations limited to the aorta. Life expectancy of patients withTAA has improved markedly in the last decades, but still remains lower than that of the general population.

Conditions

• Thoracic Aortic Aneurysm (TAA)

Interventions

Type	Name	Description
OTHER	Journey to diagnosis	Questions relating to the course and experience/history of the disease from the onset of symptoms to confirmation of diagnosis; accessibility to referral facilities for treatment and follow-up.
OTHER	Quality of life, functional health and well-being	Qestionnaires
OTHER	Awareness and self-esteem, acceptance of the condition	questionnaire related to the quality of life and self-care
OTHER	psychological and physical well-being	questionnaire to describe psychological and physical well-being.

Timeline

• Start date: 2025-05-06
• Primary completion: 2026-12-01
• Completion: 2027-05-01
• First posted: 2026-02-05
• Last updated: 2026-02-05

Locations

1 site across 1 country: Italy