NCT07391007

Integrated Clinical-molecular Risk Stratification to Early Recurrence in Colorectal Liver Metastases

A Multidimensional Early-Recurrence Risk Stratification System and Personalized Treatment for Colorectal Cancer Liver Metastases: A Prospective Clinical Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to develop an integrated clinical-molecular risk stratification to identifypatients who are at high risk of recurrence and who would benefit from adjuvant chemotherapy in patients with recectable colorectal liver metastases. The main question it aims to answer is: can the integration of multi-dimensional data-including ctDNA, driver gene profiles, and clinical factors-accurately identify postoperative patients at high risk of recurrence and guide personalized adjuvant therapy strategies?

Conditions

• Colorectal Liver Metastases

Interventions

Type	Name	Description
OTHER	gene sequencing	All patients will be performed gene sequencing in this study
OTHER	observational study	Observational Study

Timeline

• Start date: 2026-01-31
• Primary completion: 2028-04-30
• Completion: 2028-04-30
• First posted: 2026-02-05
• Last updated: 2026-02-05

Locations

1 site across 1 country: China