NCT07389824

Efficacy of Acupuncture-Mesalazine Combination Therapy in Ulcerative Colitis.

Efficacy of Acupuncture Combined With Mesalazine in Inducing and Maintaining Clinical Remission in Mild-to-Moderate Active Ulcerative Colitis: A Single-Center, Randomized Controlled Clinical Trial.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Qin Yu · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the efficacy and safety of acupuncture combined with mesalazine (an integrated acupuncture-medication regimen) for ulcerative colitis.

Detailed description

1. A randomized controlled trial. 2. Acupuncture treatment(intradermal thumbtack needle embedding), placebo control. 3. To explore the efficacy and safety of acupuncture(intradermal thumbtack needles embedding) as an adjuvant therapy for active ulcerative colitis. 4. To explore the potential relevant mechanisms.

Conditions

• Ulcerative Colitis

Interventions

Type	Name	Description
DEVICE	Acupuncture	Intradermal thumbtack needle embedding at specified acupoints. Needles are embedded for up to 72 hours, replaced weekly for 12 weeks. Patients press needles 3-5 times daily to elicit deqi sensation.
DEVICE	Sham acupuncture	Application of needle-free adhesive placebo patches at non-acupoint sites. Patches are replaced weekly for 12 weeks. Patients apply gentle pressure 3-5 times daily without deqi sensation.
DRUG	Mesalazine	Standard background therapy: Mesalazine at a stable dose (e.g., 2-4g/day) maintained throughout the 12-week study period. This provides the background treatment for both groups, allowing evaluation of the additive effect of acupuncture.

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-09-30
• Completion: 2027-12-31
• First posted: 2026-02-05
• Last updated: 2026-02-05

Locations

1 site across 1 country: China