NCT07389447

Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity

FUS of the Dentate Nucleus and Superior Cerebellar Peduncle of the Cerebellum Induces Changes to EEG Power Bands, Spatiotemporal Dynamics, and Cognitive Function in Healthy Humans

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40. The main questions it aims to answer are: Does FUS applied to the cerebellum affect cognition? Does FUS applied to the white matter or gray matter of the cerebellum with the same parameters result in different outcomes? Researchers will compare active and sham stimulations. Participants will be asked to complete cognitive tasks after receiving FUS to the cerebellum.

Conditions

• Stroke
• Trauma
• Cognition
• Agency
• Verbal Memory
• CCAS

Interventions

Type	Name	Description
PROCEDURE	Focused ultrasound	Focused ultrasound stimulation administered to the cerebellar nucleus or efferent fiber tract.
DIAGNOSTIC_TEST	EEG	This is the electroencephalography reading that will show changes in brain activity as describes in outcome measures

Timeline

• Start date: 2024-02-05
• Primary completion: 2025-12-31
• Completion: 2026-07-31
• First posted: 2026-02-05
• Last updated: 2026-02-05

Locations

1 site across 1 country: United Kingdom