NCT07389304

[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers]

[EFFECTS OF SELECTED STATINS ON CARDIOVASCULAR PARAMETERS IN HEALTHY VOLUNTEERS: A RANDAMOZIED PHASE I CLINICAL TRIAL]

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Shaheed Benazir Bhutto University Sheringal Dir Upper · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.

Detailed description

The goal of this study is to evaluate the effects of these three statins on the cardiovascular parameters in a dose-dependent manner. In this Phase 1 clinical trial we will enroll healthy volunteers who will be randomized to receive one of three statins at low, moderate, or high doses for two days. .

Conditions

• Lipid Profile,Blood Pressure

Interventions

Type	Name	Description
DRUG	Rosuvastatin (5mg, 20mg, 40mg)	The Rosuvastatin (5mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
DRUG	Atorvastatin (10mg, 20mg, 40mg)	The Atorvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
DRUG	Simvastatin (10mg, 20mg, 40m	The Simvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days

Timeline

• Start date: 2026-03-01
• Primary completion: 2026-12-30
• Completion: 2027-02-20
• First posted: 2026-02-05
• Last updated: 2026-02-05

Locations

1 site across 1 country: Pakistan