NCT07387172

Relationships of B-cell Activating Factor Gene Polymorphisms With Crohn's Disease.

Relationships of B-cell Activating Factor Gene Polymorphisms With the Risk and Clinicopathological Features of Crohn's Disease.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 824 (actual)
• Sponsor: Second Affiliated Hospital of Wenzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

From January 2020 to December 2024, Crohn's disease(CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The aim of this research is to explore the associations of B-cell activating factor(BAFF) gene polymorphisms with the risk and clinicopathological characteristics of CD.

Detailed description

From January 2020 to December 2024, a total of 310 CD patients and 514 gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.The genotypes of BAFF were determined by multiplex polymerase chain reaction-ligase detection reaction technique. Unconditional logistic regression was employed to analyze the distribution of BAFF gene polymorphisms between CD group and normal control group, as well as their influences on the clinicopathological characteristics of CD patients.

Conditions

• Crohn Disease

Timeline

• Start date: 2020-01-01
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2026-02-04
• Last updated: 2026-02-04

Locations

1 site across 1 country: China