NCT07386288

Short-term Perfusion Effects: Dexketoprofen/Tramadol

Short-term Effects of Intravenous Dexketoprofen Trometamol and Tramadol on Perfusion-Related Physiological Parameters in Renal Colic

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Background: Acute renal colic is a common reason for admission to the emergency department (ED) and is associated with severe pain, sympathetic activation and metabolic stress. Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are widely used for analgesia, but their short-term effects on tissue perfusion and respiratory physiology in stable patients are unclear. End-tidal carbon dioxide (EtCO₂) has been suggested as a non-invasive indicator of overall tissue perfusion, but how it behaves during analgesic treatment in stable ED patients is unclear. Methods: This prospective, randomised study was conducted in an academic emergency department. Adult patients (aged 18-55) presenting with acute renal colic were randomised to receive an intravenous infusion of either dexketoprofen trometamol (50 mg), tramadol (100 mg), or a combination of dexketoprofen trometamol (50 mg) and tramadol (50 mg). Vital signs, oxygen saturation (SpO₂) and EtCO₂ were recorded at baseline and at 30 and 60 minutes. Arterial blood gas parameters, including lactate, were measured at baseline and after 60 minutes. The primary outcome was the change in EtCO₂ over time.

Conditions

• Renal Colic

Interventions

Type	Name	Description
DRUG	Tramadol	Intravenous tramadol administered for analgesia in patients with renal colic.
DRUG	Dexketoprofen Trometamol	Intravenous dexketoprofen trometamol administered for analgesia in patients with renal colic
DRUG	IV Tramadol + IV Dexketoprofen Trometamol	Intravenous dexketoprofen trometamol and tramadol administered for analgesia in patients with renal colic

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-04-30
• Completion: 2025-04-30
• First posted: 2026-02-04
• Last updated: 2026-02-04

Locations

1 site across 1 country: Turkey (Türkiye)