NCT07385040

Comparison of IV Lignocain and IV Dexmedetomidine for Attenuation of Laryngoscopic Stress Response to Direct Laryngoscopy

Comparison of Intravenous Lignocain and Intravenous Dexmedetomidine for Attenuation of Hemodynamic Stress Response to Direct Laryngoscopy and Endotracheal Intubation

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Hemodymanic stress response to direct laryngoscopy and endotracheal intubation is a known phenomenon that occur in almost every patient undergoing general anesthesia before surgical procedure. This response leads to sudden rise in heart rate and blood pressure which may cause serious complications in compromised patients having cardiovascular diseases. There are certain drugs which are used to blunt this response and to prevent the life threatening complications. Intravenous Lignocain is commonly used drug to blunt the laryngoscopic response in our setup. Intravenous Dexmedetomidine is a newer and rarely used drug to prevent stress response to direct laryngoscopy and endotracheal intubation. This study aims to compare the efficacy of both the drugs to provide better control of complications like Arrythmias, stroke and cardiovascular instability.

Conditions

• Tachycardia
• Hypertension
• Mean Arterial Pressure

Interventions

Type	Name	Description
DRUG	Intravenous Dexmedetomidine infusion	Dexmedetomidine infusion with dose of 10mics/kg given 10min before induction
DRUG	Intravenous Lignocain	Intravenous ligoncain 1.5mg/kg given 90sec before induction.

Timeline

• Start date: 2023-04-13
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2026-02-03
• Last updated: 2026-02-03

Locations

1 site across 1 country: Pakistan