NCT07384910

Assessment of GARP Expression in Acute and Chronic Coronary Syndrome

Assessment of GARP Expression and Inflammatory Cytokines in Acute and Chronic Coronary Syndrome

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.

Conditions

• Atheroma; Heart

Interventions

Type	Name	Description
BIOLOGICAL	Arterial blood sample	An arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place.

Timeline

• Start date: 2026-02-01
• Primary completion: 2028-01-01
• Completion: 2028-01-01
• First posted: 2026-02-03
• Last updated: 2026-02-17

Locations

1 site across 1 country: Belgium