Trials / Recruiting
RecruitingNCT07384897
Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 425 (estimated)
- Sponsor
- Université Catholique de Louvain · Academic / Other
- Sex
- All
- Age
- 80 Years
- Healthy volunteers
- Accepted
Summary
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD). The investigators are studying how these immune cells can sometimes help the body defend itself, but in other cases may contribute to cancer growth or long-term lung inflammation. Although recent treatments like immunotherapy have improved cancer care, only a small proportion of patients currently benefit from these therapies. One goal of this research is to understand why some patients do not respond or develop resistance to treatment. The knowledge gained from this study may help researchers develop more effective and personalized treatments for people with lung diseases in the future.
Conditions
- Lung Cancer (Diagnosis)
- Sarcoidosis
- Chronic Obstructive Pulmonary Disease
- Immunotherapy Resistance
- Immune Dysregulation
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Peripheral Blood Collection for Immune Profiling | Participants provide biological samples for immune profiling and translational research. Samples include peripheral blood and, when available from routine clinical care, additional specimens such as tumor tissue or rlymph node, bone marrow. No experimental treatments are given. Collected samples are analyzed to characterize immune cell populations and their functional and molecular features, with the aim of studying immune mechanisms involved in lung cancer, sarcoidosis, and COPD, as well as factors associated with disease progression and treatment response. All medical care and treatment decisions remain independent of study participation. |
Timeline
- Start date
- 2025-02-17
- Primary completion
- 2030-12-01
- Completion
- 2032-02-17
- First posted
- 2026-02-03
- Last updated
- 2026-02-03
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT07384897. Inclusion in this directory is not an endorsement.