NCT07384130

Oral Probiotics for Halitosis in Healthy Adults

Efficacy of Oral Probiotics on Cysteine-Induced Halitosis in Healthy Adult Volunteers.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: John Hale · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate efficacy of a probiotic lozenge containing BLIS M18, BLIS K12 and a prebiotic in healthy adults.

Detailed description

This is a double-blind, randomized controlled colonization pilot study with no crossover to evaluate the efficacy of probiotic lozenges on halitosis in healthy adults. Participants will be randomly assigned to 2 groups consuming probiotic lozenge containing Streptococcus salivarius M18 and K12 and with prebiotic over a 13 day period. Breath scores will be measured at predetermined time points pre and post intervention.

Conditions

• Halitosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	In this study, a probiotic lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath	In this study, a probiotic-free lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath as a comparator.
OTHER	Placebo	Probiotic free placebo lozenge

Timeline

• Start date: 2026-03-15
• Primary completion: 2026-06-15
• Completion: 2026-07-15
• First posted: 2026-02-03
• Last updated: 2026-02-04

Locations

1 site across 1 country: New Zealand