NCT07383415

Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia

Assessing the Effectiveness of Combined Intranasal Platelet-rich Plasma Plus Topical Insulin Versus Platelet-rich Plasma Alone in the Treatment of Post Inflammatory Anosmia: a Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Amin Javer · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia. Participants will be randomly assigned to receive either intranasal PRP combined with topical insulin or intranasal PRP alone. Changes in olfactory function will be assessed over time to compare the effectiveness and safety of the two treatments.

Detailed description

Post-inflammatory anosmia is a common cause of persistent olfactory dysfunction with limited effective treatment options. Platelet-rich plasma (PRP) has been proposed as a regenerative therapy due to its high concentration of growth factors, while topical insulin has demonstrated potential neurotrophic and anti-inflammatory effects in olfactory tissue. This randomized controlled trial aims to evaluate whether the addition of topical insulin to intranasal PRP provides greater improvement in olfactory function compared with intranasal PRP alone in adults with post-inflammatory anosmia. Participants will be randomly assigned to receive either combined intranasal PRP plus topical insulin or intranasal PRP alone. Olfactory function will be assessed at baseline and at predefined follow-up time points using validated smell testing methods. Safety and tolerability of the interventions will also be monitored throughout the study. The results of this study will contribute to understanding the potential role of regenerative and neurotrophic therapies in the management of post-inflammatory anosmia

Conditions

• Anosmia
• Inflammatory Anosmia

Interventions

Type	Name	Description
BIOLOGICAL	Intranasal PRP Plus Topical Insulin	Autologous platelet-rich plasma administered intranasally with the addition of topical insulin applied to the olfactory cleft.
BIOLOGICAL	Intranasal PRP Plus Saline (Placebo)	Autologous platelet-rich plasma administered intranasally with saline applied in place of topical insulin as a placebo comparator.

Timeline

• Start date: 2026-03-30
• Primary completion: 2026-12-30
• Completion: 2027-01-01
• First posted: 2026-02-03
• Last updated: 2026-02-03