NCT07382362

Preventing Neurologic Complications in Valve Surgery

Strategies for the Prevention of Perioperative Neurological Complications in Cardiac Valve Surgery

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: China National Center for Cardiovascular Diseases · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In patients with valvular heart disease and atrial fibrillation (AF) undergoing surgical valve surgery, current guidelines recommend concomitant surgical management of the left atrial appendage (LAA) to prevent postoperative thromboembolic events, particularly neurologic embolic events. However, whether concomitant LAA management benefits patients without AF by reducing postoperative neurologic complications remains controversial. Given these uncertainties, this study aims to evaluate whether concomitant LAA suture closure during surgical valve surgery is associated with a lower incidence of perioperative silent cerebral infarction.

Conditions

• Left Atrial Appendage Closure

Interventions

Type	Name	Description
PROCEDURE	Left Atrial Appendage (LAA) Suture Closure	Concomitant suture closure of the LAA performed at the time of surgical valve surgery, at the discretion of the operating surgeon.
PROCEDURE	Surgical Valve Surgery	Standard surgical valve repair or replacement performed according to routine clinical practice.

Timeline

• Start date: 2026-01-27
• Primary completion: 2028-01-31
• Completion: 2028-07-31
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

4 sites across 1 country: China