NCT07381959

Biomarkers of Brain Injury in Children With Brain Tumors

Biomarkörer för hjärnskada Hos Barn Med hjärntumör

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 560 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 17 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is: Can investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors? Researchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers. Participants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.

Conditions

• Brain Tumor
• Childhood Cancer
• Childhood Brain Tumor

Timeline

• Start date: 2021-08-01
• Primary completion: 2031-12-31
• Completion: 2031-12-31
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Sweden