NCT07381816

GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with postprandial hypotension.

Detailed description

Each participant will attend three independent randomised experimental days in the MRI-scanner with intravenous infusion (hormone/placebo) and oral ingestion (glucose): An intravenous infusion of saline or GIP(3-30)NH2 starts at time point -20 minutes.The infusions are combined with an oral glucose tolerance test (75 gram of glucose dissolved in 250 ml water ingested orally) at time point 0 minutes on two of the experimental days (with and without GIP(3-30)NH2). Furthermore one day will be with handgrip exercise, without an infusion. Therefore the first two days are in randomized order. MRI measurements are repeatedly performed and blood samples are drawn to be analysed for endocrine responses from the intestines and pancreas.

Conditions

• Postprandial Hypotension
• Healthy
• Blood Flow

Interventions

Type	Name	Description
OTHER	MRI + GIPR antagonist (Tool)	GIP(3-30)NH2 infusion, oral glucose during MRI scans
OTHER	MRI + hangrip	Hangrip exercises, oral glucose during MRI scans
OTHER	Saline and oral glucose	Saline infusion oral glucose during MRI scans

Timeline

• Start date: 2025-09-15
• Primary completion: 2026-12-01
• Completion: 2027-05-01
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Denmark