NCT07380568

Melatonin on Post Operative Pain After CS

The Effect of Preoperative Oral Melatonin on Postoperative Pain Control After Cesarean Section: A Dose Comparison Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Benha University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if melatonin will decrease pain after C.S. The main questions it aims to answer are: Does melatonin lower the number of times participants need to use a rescue analgesia? What medical problems do participants have when taking melatonin? Researchers will compare different doses of melatonin to see the ideal dose to decrease pain after C.S. Participants will: Take melatonin 30 min before C.S and will be observed for 24 hours for pain and consumption of other analgesia

Conditions

• Pain Management
• Pain After Surgery
• Cesarean Section Pain

Interventions

Type	Name	Description
DRUG	Melatonin 5 mg	Group I: (5 mg melatonin): Participants will receive 5 mg of oral melatonin 1 hours before the cesarean section.
DRUG	Melatonin 10 mg	Group II: (10 mg melatonin): Participants will receive 10 mg of oral melatonin 1 hours before the cesarean section.
DRUG	Placebo	Group III: (Placebo): Participants will receive an identical placebo tablet 1 hours before the cesarean section.

Timeline

• Start date: 2025-10-10
• Primary completion: 2026-03-01
• Completion: 2026-04-01
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Egypt