NCT07380425

Deep Breathing With and Without Pressure Support and PEEP for Preoxygenation in Obese Patients

Effects of Pressure Support and Positive End-Expiratory Pressure Added to Deep Breathing Preoxygenation on Gastric Distension in Obese Patients: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Pamukkale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Obese patients are at increased risk of low oxygen levels during the induction of general anesthesia. Preoxygenation with a face mask before anesthesia is routinely used to increase oxygen reserves. This study compares three preoxygenation techniques: deep breathing alone, deep breathing with pressure-supported ventilation, and deep breathing with pressure-supported ventilation plus positive end-expiratory pressure (PEEP). The main goal of the study is to determine how quickly each technique allows patients to reach an adequate level of oxygen in the lungs. In addition, the study evaluates whether these techniques cause gastric distension, which could increase the risk of regurgitation. Gastric ultrasound is used to assess stomach size before and after preoxygenation. The results of this study will help identify the most effective and safest method of preoxygenation in obese patients undergoing elective surgery.

Conditions

• Obesity

Interventions

Type	Name	Description
PROCEDURE	Deep Breathing Preoxygenation	Preoxygenation performed with deep breathing using a ventilator delivering 100% oxygen at a flow rate of 12 L/min.
PROCEDURE	Pressure Support Ventilation	Application of pressure support ventilation with a pressure support level of 12 cmH₂O during preoxygenation.
PROCEDURE	Positive End-Expiratory Pressure	Application of positive end-expiratory pressure at a level of 6 cmH₂O during preoxygenation.

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-07-25
• Completion: 2022-07-25
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Turkey (Türkiye)