NCT07380373

Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome

Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomazrkers in Pediatric Acute Respiratory Distress Syndrome

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 37 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 1 Year – 10 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion. and to compare the validity of cytokines in BAL versus salivary secretion in predicting the stage of ARDS and disease outcome in term of mortality, disease progression and length of stay.

Detailed description

• BAL will be performed by the attending pediatric intensivist in pediatric intensive care unit as part of standard care for ARDS management and Saliva samples will be collected non-invasively using sterile collection devices IL6 and TNF alfa will measured in both samples and compared to each other

Conditions

• ARDS (Acute Respiratory Distress Syndrome)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Bronchoscopy	Comparison between levels of inflammatory markers in both BAL \&salivary secretions

Timeline

• Start date: 2025-05-01
• Primary completion: 2026-04-01
• Completion: 2026-06-01
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Egypt