NCT07380009

Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy.

Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy: a Randomized, Open-label Clinical Trial.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Thessaly · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This open-label interventional study aims to evaluate the acceptability and adherence of adult participants to the multistrain probiotic Vivomixx® 460 Neo 9 when administered concurrently with antibiotic therapy. Participants are randomized to receive one of two dosing regimens: a low daily dose or a high daily dose. The study will assess the effects of these regimens on the prevention of antibiotic-associated diarrhea (AAD), gastrointestinal symptoms, and patient adherence and acceptability. The results are intended to provide evidence to optimize the clinical use of probiotics alongside antibiotics.

Conditions

• Antibiotic Therapy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	One sachet of the probiotic daily	Twenty participants will receive one sachet of the probiotic daily.
DIETARY_SUPPLEMENT	Two sachets of the probiotic daily	Twenty participants will receive two sachets of the probiotic daily.

Timeline

• Start date: 2025-12-12
• Primary completion: 2026-05-30
• Completion: 2026-05-30
• First posted: 2026-02-02
• Last updated: 2026-02-02

Locations

1 site across 1 country: Greece