NCT07378228

Weak Pulse at Yang and Wiry Pulse at Yin Theory

Clinical Application and Mechanistic Study of National Traditional Chinese Medicine Master Lu Fang's "Weak Pulse at Yang and Wiry Pulse at Yin" Theory in Treating Angina Pectoris of qi Deficiency and Blood Stasis Pattern Secondary to Coronary Heart Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Xikun Li · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This is a clinical study to evaluate the effectiveness and explore the possible working mechanisms of a traditional Chinese herbal formula called Yixin Powder. The study focuses on patients with stable angina pectoris (chest pain) caused by coronary heart disease (CHD), who are diagnosed with a specific Chinese medicine pattern known as "qi deficiency and blood stasis," based on the "weak pulse at yang and wiry pulse at yin" theory. The study hypothesizes that adding Yixin Powder to standard Western medication will be beneficial for these patients. To test this, participants diagnosed with this condition will be randomly assigned to one of two groups. One group will receive standard medication alone, while the other group will receive the same standard medication plus Yixin Powder. The effects of the treatments will be compared between the two groups.

Conditions

• Coronary Heart Disease
• Stable Angina Pectoris

Interventions

Type	Name	Description
DRUG	Metoprolol Succinate Extended-Release Tablets	Metoprolol succinate extended-release tablets, 23.75 mg administered orally once daily.
DRUG	Aspirin Enteric-Coated Tablets	Aspirin enteric-coated tablets, 100 mg administered orally once daily.
DRUG	Atorvastatin Calcium Tablets	Atorvastatin calcium tablets, 20 mg administered orally once daily.
DRUG	Yixin Powder	A traditional Chinese herbal formula composed of red ginseng (5 g), pseudo-ginseng powder (3 g), dragon's blood (1 g), leech (3 g), succinite (3 g), Chinese hawthorn fruit (10 g), and myrrh (5 g). Prepared by the hospital formulary. Administered orally at a total daily dose of 30 g, divided into two 15 g portions taken morning and evening.

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-06-01
• Completion: 2024-06-01
• First posted: 2026-01-30
• Last updated: 2026-01-30

Locations

1 site across 1 country: China