NCT07377903

Post Operative Shivering Following Anesthesia

Pharmacological Management of Post Operative Shivering Following Anesthesia

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to compare the efficacy of magnesium sulphate, ondansetron, and dexmedetomidine in managing post-spinal anesthesia shivering. The primary aim is the time to cessation of shivering after drug administration, while secondary aim include hemodynamic parameters (heart rate, blood pressure, SpO₂ ) and the recurrence of shivering

Detailed description

This is a randomized double blinded study including patients undergoing surgery under spinal anesthesia. Patients will be randomly allocated into three groups to receive magnesium sulphate, ondansetron, or dexmedetomidine for the treatment of post-spinal anesthesia shivering. The time to cessation of shivering, hemodynamic parameters, and recurrence of shivering will be recorded.

Conditions

• Shivering, Spinal Anesthesia

Interventions

Type	Name	Description
DRUG	Dexmedetomidin	•Group D (Dexmedetomidine Group): 0.5 µg/kg dexmedetomidine diluted in 100 mL of normal saline.
DRUG	Mg (magnesium sulfate)	50 mg/kg magnesium sulphate diluted in 100 mL of normal saline.
DRUG	Ondansetron 8 mg	8 mg ondansetron diluted in 100 mL of normal saline.

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-07-01
• Completion: 2026-09-01
• First posted: 2026-01-30
• Last updated: 2026-02-04