NCT07375667

Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients

Mechanisms of Dynamic Airway Resistance Monitoring and Machine Learning for Assessing Pulmonary Inflammation and Guiding Sputum Suction in Mechanically Ventilated Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 258 (estimated)
• Sponsor: Affiliated Hospital of Nantong University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \[10\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.

Detailed description

To validate the clinical feasibility and reliability of airway viscous resistance monitoring, explore the temporal correlation between inflammatory biomarkers and changes in airway viscous resistance, establish a reference threshold system for special populations, and provide experimental evidence for determining the optimal suctioning timing.

Conditions

• Mechanical Ventilation Pressure High
• Ventilator-Associated Pneumonia (VAP)
• Respiratory Depression Neonatal

Interventions

Type	Name	Description
PROCEDURE	The dynamics of airway resistance	Monitoring the dynamic changes in airway resistance in patients can be used to reflect the progression of pulmonary inflammation and determine the optimal timing for suctioning.
DIAGNOSTIC_TEST	conventional suctioning	The timing for suctioning is determined based on clinical signs such as rhonchi and an elevated peak pressure.

Timeline

• Start date: 2025-10-30
• Primary completion: 2028-12-30
• Completion: 2029-12-30
• First posted: 2026-01-29
• Last updated: 2026-01-29

Locations

3 sites across 1 country: China