NCT07374978

Effect of Thrombolysis on 30-day Mortality in Intermediate High Risk Pulmonary Patients With Low Bleeding Risk

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 25 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The aim of investigators was to study the effect and safety of Thrombolysis in Intermediate high risk pulmonary embolism patients with low bleeding risk as regards Mortality and bleeding events.

Detailed description

InvestIgators aimed to determine the effect of thrombolysis in Intermediate high risk pulmonary embolism patients with low bleeding risk as regards mortality and bleeding events. Study design : randomized clinical study conducted Ain Shams University Hospitals over 2 years duration , included 100 participants divided into two groups; control group (50) and study group (50). Participants assigned to the control group received standard treatment in the form of anticoagulation (intravenous unfractionated heparin) whole participant assigned to control group received thrombolytic therapy (streptokinase or recombinant tissue plasminogen activator) Investigators performed baseline echocardiography for all participants before receiving treatment and assessment of bleeding risk using HASBLED score Follow up of participants' vital data was done in a monitored care unit Participants were assessed one month later for dyspnea and its grade and follow up echocardiography was done also.

Conditions

• Pulmonary Embolism Subacute Massive
• Thrombolytic Therapy

Interventions

Type	Name	Description
DRUG	Thrombolytic therapy for the study group in the form of streptokinase or recombinant tissue plasminogen activator	Thrombolytic therapy acting on thrombus in pulmonary embolism patients
DRUG	Unfractionated Heparin IV	Standard anticoagulation

Timeline

• Start date: 2023-07-01
• Primary completion: 2025-05-01
• Completion: 2025-07-01
• First posted: 2026-01-29
• Last updated: 2026-01-29

Locations

1 site across 1 country: Egypt